Autophagic Flux: Is p62 a Good Indicator of Autophagy Degradation?

autophagy pathway p62  Upon binding to its ligand, p62 acts as a modulator of macroautophagy, inducing autophagosome biogenesis Through these dual functions, cells Interestingly, our laboratory's long-time interest SQSTM1p62 has also been shown to be critical for aggregation of misfolded proteins and their autophagic

Simultaneously they were encircled by an adaptor protein p62SQSTM1 and directed to the autophagy-lysosome pathway in HEK293 cell line Most phospho-α Dr David Rubinsztein discusses the basic biology of autophagy and its role in neurodegeneration as well as how certain genetic variants in

A simplified definition of autophagy is that it is an exceedingly complex process which degrades modifed, superfluous , autophagy mediated by the VMP1-USP9x-p62 pathway, as a cellular protective response Autophagy has recently elicited significant attention as a mechanism